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About BRC (BioResource Research Center)

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What are Bioresources?

What are Bioresources (for first visitor) ?

Experimental Animal Division
Experimental Animal Division
* Collection, preservation, quality-control and distribution of mouse resources useful for basic researches to understand the higher-order biological phenomena and to conquer human complex diseases.
* Development of novel mouse resources which meet social and research needs and relevant technologies for preservation, distribution and quality control.
* Contribution to the promotion of life sciences by offering training courses to disseminate advanced technologies for the best use and quality control of mouse resources in collaboration with global mouse repositories.
Experimental Plant Division
Experimental Plant Division
* Collection, preservation and distribution of Arabidopsis resources that are indispensable for plant science.
* Establishment of research infrastructure of Brachypodium distachyon, a model crop that contributes innovation in agriculture.
* Development and propagation of plant cultured cells, DNA materials and related technologies that promote studies on the environment, food, and production of useful materials.
Cell Engineering Division
Cell Engineering Division
* Collection and distribution of the following cells: cultured cell lines such as human cancer cell lines; stem cells such as ES cells, iPS cells (including disease-specifi c iPS cells) and human somatic stem cells; cells for human genome research.
* Accepting donation and deposition of cells that have been developed by life science community, carrying out quality control of them, standardizing them, and distributing high quality cell materials to all scientists around the world.
* Offering training courses of the technologies relating to cell culture, so as to contribute to the development of new technology such as human ES cells and iPS cells.
Gene Engineering Division
Gene Engineering Division
* Cutting edge resources that can accelerate researches that contribute to the elucidation of higher-order biological phenomena and the cause of diseases, the development of medical treatment, the drug discovery research and/or the problems in environment: reporter vectors visualizing biological activity, effi cient gene transduction and expression vectors.
* Highly useful and convenient resources: variety of standard DNAs extracted from microorganisms, mice and cultured cells and ready-to-use expression vectors.
* Highly reliable biological resources with highest quality: quality tests under rigorous control and abundant literatures and information of biological characteristics.
Microbe Division
Microbe Division
* Preservation and provision of scientifically important microbial strains representing diverse species of Bacteria, Archaea, and Fungi.
* Collection of microbial bioresources that contribute to environmental and health science, enrichment of information of the strains in the database, and development of related technology.
* Provision of reliable high-quality microbial cultures by intensive quality control with genetic and physiological tests and stable preservations.
Integrated Bioresource Information Division
Integrated Bioresource Information Division
* Collection, analysis, management of bioresource information and its dissemination to research communities through the web-based catalogs.
* Improvement of technologies for sharing and application of bioresouce-related information in the Internet.
* Analysis and visualization of large-scale data to promote expanding uses and values of bioresources and contribution to solving various problems of human beings.
Bioresource Engineering Division
Bioresource Engineering Division
* Nuclear transfer cloning: Establishment of an effi cient technique for production of cloned mice. A great leap to the practical use of cloning technology in mammals.
* Microinsemination (sperm injection): Production of normal mice using not only normal mature spermatozoa, but also immature spermatids and spermatozoa retrieved from frozen mouse bodies.
* Cryopreservation of embryos and germ cells and their transportation: Development of embryo cryopreservation techniques applicable to a variety of mouse strains. Safe transportation of vitrifi ed embryos in dry ice packages to avoid the use of dry shippers.
* Establishment of new stem cell lines: Mouse ES cells with different characters and different origins. Rabbit ES cells and iPS cells with potential usefulness as new experimental models.
* Technical training courses: Cryopreservation of mouse sperm and embryos, and establishment and maintenance of mouse embryonic stem cells.
Technology and Development Team for Mammalian Genome Dynamics
Technology and Development Team for Mammalian Genome Dynamics
* Technology development for functional genomic analysis: methods for high resolution genotyping and genome manipulation utilizing high quality BAC genomic resources.
* Technology development for characterization of embryo-derived stem cells and germ cells: analysis of molecular and epigenetic features of these cell types using novel imaging techniques and genomic analyses at single-cell level.
* Technology development for bioimaging: analysis of cellular behaviors and functions in vivo utilizing an intravital microscope equipped with novel stick-type lenses.
Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic
Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic
* Systematic and comprehensive phenotypic analyses for genetically-modifi ed mice based on the fundamental and in-depth pipelines in the Japan Mouse Clinic.
* Contribution to international mouse phenotyping project through the participation to International Mouse Phenotying Consortium (IMPC).
* Intellectual infrastructure for the mouse resource through the integration of mouse phenotype information with the related clinical data on human diseases.
* Development of new phenotyping methods to analyze mouse resources.
iPSC-based Drug Discovery and Development Team
iPSC-based Drug Discovery and Development Team
* Leading drug discovery technology that will open a avenue for new medicines.
* Using iPS cells of BioResource Center to develop infrastructure technology for drug discovery and medical study.
* Bridging RIKEN BRC and academia/industry in the fi eld of translational iPS cell research.
* Engage in the development of drug discovery researches using disease-specifi c iPS cells of RIKEN BRC cellbank at Keihanna in collaborating with the Cell Engineering Division, and Center for iPS Cell Research and Application (CiRA), Kyoto University.
iPS Cell Advanced Characterization and Development Team
iPS Cell Advanced Characterization and Development Team
* Advanced characterization (e.g., pluripotency and genome) of disease-specific iPS cells deposited in RIKEN cell bank.
* Development of modified (e.g., mutation-corrected, mutation-introduced, and reporter-introduced) iPS cells using genome-editing technologies.
* Development of differentiation system and disease models using disease-specific iPS cells deposited in RIKEN cell bankcollaborative researches with domestic and international research communities.
Next Generation Human Disease Model Team
Next Generation Human Disease Model Team
* Development of mouse models faithfully recapitulating genomic mutations and pathology of designated intractable diseases or diseases of the aged based on the patients' genome information by the genome modification technology.
* Analyses and evaluation of the mouse models through the standard, disease-specific and ageing-specific phenotyping platforms of the international standard.
* Establishment of POC in preclinical studies by investigating disease mechanisms and pharmacokinetics in collaboration with experts.
* Provision of disease models with useful information for diagnosis, therapies and drug discovery to biomedical research community.
Plant-Microbe Symbiosis Research and Development Team
Plant-Microbe Symbiosis Research and Development Team
* Elucidation of the symbiosis between plants and rhizosphere microbes including mycorrhizal fungi.
* Construction of bioresources and experimental systems of experimental plants and rhizosphere microbes for the symbiosis studies.
* Contribution to building a sustainable solution for world food and environmental problems through collaborative researches with domestic and international research communities.
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New Information Close

  • Nov 27, 2018
    E-mail News Delivery (Experimental Plant Division)
    Nov 26, 2018
    Control Vectors Updates (Gene Engineering Division)
    Nov 22, 2018
    Data Updates (Experimental Animal Division)
    Nov 19, 2018
    Notice: Scheduled System Maintenance: Fri, Nov 16 13:00 - Mon, Nov 19 13:00  completed
    Nov 08, 2018
    Announcement of our exhibition during Consortium of "The 47th Annual Meeting of The Japanese Society for Immunology".  Closed
    Nov 07, 2018
    Announcement of our exhibition during Consortium of "Agribusiness Creation Fair 2018".  Closed
    Nov 06, 2018
    Regulation of phytohormone in plant adaptation to drought
    – Discovery of a regulating factor in plant hormone biosynthesis under dehydration stress –
    Nov 06, 2018
    Announcement of our exhibition during Consortium of "The 41th Annual Meeting of the Molecular Biology Society of Japan".  Closed
    Oct 31, 2018
    E-mail News Delivery (Cell Engineering Division)
    Oct 26, 2018
    Data Updates (Experimental Animal Division)
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BRC Pamphlet
License agreement between Clontech and RIKEN BRC on Fluorescent Proteins
Quality Examination and Information Release Policy on Our Bioresources
International Program Associate