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About BRC (BioResource Research Center)

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What are Bioresources?

What are Bioresources (for first visitor) ?

Experimental Animal Division
Experimental Animal Division
* Collection, preservation, quality-control and distribution of mouse resources useful for basic researches to understand the higher-order biological phenomena and to conquer human complex diseases.
* Development of novel mouse resources which meet social and research needs and relevant technologies for preservation, distribution and quality control.
* Contribution to the promotion of life sciences by offering training courses to disseminate advanced technologies for the best use and quality control of mouse resources in collaboration with global mouse repositories.
Experimental Plant Division
Experimental Plant Division
* Collection, preservation and distribution of Arabidopsis resources that are indispensable for plant science.
* Establishment of research infrastructure of Brachypodium distachyon, a model crop that contributes innovation in agriculture.
* Development and propagation of plant cultured cells, DNA materials and related technologies that promote studies on the environment, food, and production of useful materials.
Cell Engineering Division
Cell Engineering Division
* Collection and distribution of the following cells: cultured cell lines such as human cancer cell lines; stem cells such as ES cells, iPS cells (including disease-specifi c iPS cells) and human somatic stem cells; cells for human genome research.
* Accepting donation and deposition of cells that have been developed by life science community, carrying out quality control of them, standardizing them, and distributing high quality cell materials to all scientists around the world.
* Offering training courses of the technologies relating to cell culture, so as to contribute to the development of new technology such as human ES cells and iPS cells.
Gene Engineering Division
Gene Engineering Division
* Cutting edge resources that can accelerate researches that contribute to the elucidation of higher-order biological phenomena and the cause of diseases, the development of medical treatment, the drug discovery research and/or the problems in environment: reporter vectors visualizing biological activity, effi cient gene transduction and expression vectors.
* Highly useful and convenient resources: variety of standard DNAs extracted from microorganisms, mice and cultured cells and ready-to-use expression vectors.
* Highly reliable biological resources with highest quality: quality tests under rigorous control and abundant literatures and information of biological characteristics.
Microbe Division
Microbe Division
* Preservation and provision of scientifically important microbial strains representing diverse species of Bacteria, Archaea, and Fungi.
* Collection of microbial bioresources that contribute to environmental and health science, enrichment of information of the strains in the database, and development of related technology.
* Provision of reliable high-quality microbial cultures by intensive quality control with genetic and physiological tests and stable preservations.
Integrated Bioresource Information Division
Integrated Bioresource Information Division
* Collection, analysis, management of bioresource information and its dissemination to research communities through the web-based catalogs.
* Improvement of technologies for sharing and application of bioresouce-related information in the Internet.
* Analysis and visualization of large-scale data to promote expanding uses and values of bioresources and contribution to solving various problems of human beings.
Bioresource Engineering Division
Bioresource Engineering Division
* Nuclear transfer cloning: Establishment of an effi cient technique for production of cloned mice. A great leap to the practical use of cloning technology in mammals.
* Microinsemination (sperm injection): Production of normal mice using not only normal mature spermatozoa, but also immature spermatids and spermatozoa retrieved from frozen mouse bodies.
* Cryopreservation of embryos and germ cells and their transportation: Development of embryo cryopreservation techniques applicable to a variety of mouse strains. Safe transportation of vitrifi ed embryos in dry ice packages to avoid the use of dry shippers.
* Establishment of new stem cell lines: Mouse ES cells with different characters and different origins. Rabbit ES cells and iPS cells with potential usefulness as new experimental models.
* Technical training courses: Cryopreservation of mouse sperm and embryos, and establishment and maintenance of mouse embryonic stem cells.
Technology and Development Team for Mammalian Genome Dynamics
Technology and Development Team for Mammalian Genome Dynamics
* Technology development for functional genomic analysis: methods for high resolution genotyping and genome manipulation utilizing high quality BAC genomic resources.
* Technology development for characterization of embryo-derived stem cells and germ cells: analysis of molecular and epigenetic features of these cell types using novel imaging techniques and genomic analyses at single-cell level.
* Technology development for bioimaging: analysis of cellular behaviors and functions in vivo utilizing an intravital microscope equipped with novel stick-type lenses.
Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic
Technology and Development Team for Mouse Phenotype Analysis: Japan Mouse Clinic
* Systematic and comprehensive phenotypic analyses for genetically-modifi ed mice based on the fundamental and in-depth pipelines in the Japan Mouse Clinic.
* Contribution to international mouse phenotyping project through the participation to International Mouse Phenotying Consortium (IMPC).
* Intellectual infrastructure for the mouse resource through the integration of mouse phenotype information with the related clinical data on human diseases.
* Development of new phenotyping methods to analyze mouse resources.
iPSC-based Drug Discovery and Development Team
iPSC-based Drug Discovery and Development Team
* Leading drug discovery technology that will open a avenue for new medicines.
* Using iPS cells of BioResource Center to develop infrastructure technology for drug discovery and medical study.
* Bridging RIKEN BRC and academia/industry in the fi eld of translational iPS cell research.
* Engage in the development of drug discovery researches using disease-specifi c iPS cells of RIKEN BRC cellbank at Keihanna in collaborating with the Cell Engineering Division, and Center for iPS Cell Research and Application (CiRA), Kyoto University.
iPS Cell Advanced Characterization and Development Team
iPS Cell Advanced Characterization and Development Team
* Advanced characterization (e.g., pluripotency and genome) of disease-specific iPS cells deposited in RIKEN cell bank.
* Development of modified (e.g., mutation-corrected, mutation-introduced, and reporter-introduced) iPS cells using genome-editing technologies.
* Development of differentiation system and disease models using disease-specific iPS cells deposited in RIKEN cell bankcollaborative researches with domestic and international research communities.
Next Generation Human Disease Model Team
Next Generation Human Disease Model Team
* Development of mouse models faithfully recapitulating genomic mutations and pathology of designated intractable diseases or diseases of the aged based on the patients' genome information by the genome modification technology.
* Analyses and evaluation of the mouse models through the standard, disease-specific and ageing-specific phenotyping platforms of the international standard.
* Establishment of POC in preclinical studies by investigating disease mechanisms and pharmacokinetics in collaboration with experts.
* Provision of disease models with useful information for diagnosis, therapies and drug discovery to biomedical research community.
Plant-Microbe Symbiosis Research and Development Team
Plant-Microbe Symbiosis Research and Development Team
* Elucidation of the symbiosis between plants and rhizosphere microbes including mycorrhizal fungi.
* Construction of bioresources and experimental systems of experimental plants and rhizosphere microbes for the symbiosis studies.
* Contribution to building a sustainable solution for world food and environmental problems through collaborative researches with domestic and international research communities.
If you want to use our bioresources

How to order bioresources

Overview the general flow to get bioresource of your interest

User support

Feel free to consult with our technical experts.

Fees to domestic users include consumption tax.
The following fees are correct as of April 1, 2014 Price is subject to change without notice.



Mice (Experimental Animal Division)

Fee (JPY)
For use in research for not-for-profit academic purpose (*5) For use in research for-profit-research purpose (*6)
Live mice (per animal) (*1)(*4) 12,400 24,800
Cryopreserved embryos Cryopreserved embryos(2 tubes) 24,200 48,400
Recovered litters from cryopreserved embryos(*1) 67,300 134,600
Cryopreserved sperm Cryopreserved sperm(2 straws) 10,400 20,800
Recovered litters from cryopreserved sperm
(*1)
106,000 212,000
Recovery of cryopreserved strains from the FIMRe members (*2) Recovered litters from cryopreserved embryos 43,100 86,200
Recovered litters from cryopreserved sperm 95,500 191,000
Chimeric mice from blastocyst injection of
ES cell clone
333,300 666,600
Mouse DNA (ten micro gram) (*3) 3,100 6,200
Additional microbe tests Culture (per test) 1,900 1,900
Serology (per test) 2,900 2,900
PCR (per test) 4,320 4,320
Microscopy (per test) 1,900 1,900
RIKEN BRC standard test (per test) 34,200 34,200
  • Fees do not include the cost of shipping containers and freight, which will be separately charged.
  • (*1) RIKEN BRC conducts routine microbe tests of animal facilities using test mice. If you request additional tests, extra fees are required.
  • (*2) The cost of shipping containers and freight will be separately charged to a user. Microbe tests of foster mothers will be conducted and the cost of the tests will also be charged to the user. In addition, when you request a frozen resource from a FIMRe organization, you need to pay fees of the resource and shipping cost of dry shipper separately.
  • (*3) You can order Mouse DNA from either the Experimental Animal Division or the Gene Engineering Division. Shipments will be made by the Gene Engineering Division.
  • (*4) If you wish to request organs or tissues, please contact the Experimental Animal Division (animal@brc.riken.jp).
  • (*5) This refers to the use of our bioresource in research for not-for-profit academic purpose by a non-profit organization. Category I MTA is needed.
  • (*6) This refers to the use of our bioresource in research for the following cases. Category II MTA is needed.
    • For research to be conducted by for-profit organizations
    • For collaborative research between for-profit organization and not-for-profit organization
    • For research by not-for-profit organization outsourced and sponsored by for-profit organization
    • For for-profit research by not-for-profit organization including R&D with the aim of patent acquisition
  • For Mouse resources containing fluorescent proteins owned by, or licensed to, Clontech Laboratories, Inc., a license fee is separately required per strain.
  • For further information, please contact the Experimental Animal Division (animal@brc.riken.jp).



Experimental Plants (Experimental Plant Division)

Fee (JPY)
For use in research for not-for-profit academic purpose (*3) For use in research for-profit-research purpose (*4)
Arabidopsis Individual seed stock (50 seeds per line)(*1) 3,100 6,200
Individual seed stock (400 seeds per line) 6,300 12,600
Set of individual seed stocks (100 lines) 121,400 242,800
Set of individual seed stocks (set of 50 lines from each seed pool) 62,000 124,000
Set of pooled seeds for screening (per pool set)(*1) 6,200 12,400
Brachypodium Individual seed stock (50 seeds per line)(*1) 6,100 12,200
Individual plant DNA (per clone)(*1) 3,100 6,200
Set of individual plant DNA (per 100 clones) 121,400 242,800
DNABook™ (per volume)(*2) 35,640 -
Plant cell culture (per line)(*2) 6,200 12,400
Quarantine certificate (per certificate) 16,600 16,600
Culture media for cell suspension subculture (per unit) 1,000 1,000
Genotyping of natural accessions from RIKEN BRC (per line) 9,300 9,300
  • (*1) We offer volume discounts for orders of 10 vials/sets or more of Individual seed stocks, Set of pooled seeds and Individual plant DNA.
  • (*2) Shipping costs for the DNABook™ and Plant cell culture will be charged to overseas' users.
  • (*3) This refers to the use of our bioresource in research for not-for-profit academic purpose by a non-profit organization. Category I MTA is needed.
  • (*4) This refers to the use of our bioresource in research for the following cases. Category II MTA is needed.
    • For research to be conducted by for-profit organizations
    • For collaborative research between for-profit organization and not-for-profit organization
    • For research by not-for-profit organization outsourced and sponsored by for-profit organization
    • For for-profit research by not-for-profit organization including R&D with the aim of patent acquisition



Cell Bank (Cell Engineering Division)

Fee (JPY)
For use in research for not-for-profit academic purpose (*1) For use in research for-profit-research purpose (*2)
General cell lines (RCB) (per tube) 15,400 30,800
Human iPS cells (HPS) (per tube) 28,800 57,600(*)
Human ES cells (HES) (per tube) 28,800 57,600
Animal iPS cells (APS) (per tube) 24,700 49,400(*)
Animal ES cell lines including nuclear transferred ES cell lines and germline stem cell lines (AES) (per tube) 24,700 49,400
Nucleated cells derived from umbilical cord blood (HCB) (per sample) 32,900 65,800
Mononuclear cells derived from umbilical cord blood (CBF)-Small (per 4 tubes) 13,400 26,800
Mononuclear cells derived from umbilical cord blood (CFD)-Large (per sample) 32,900 65,800
CD34-positive cells derived from umbilical cord blood (C34) (per tube) 43,200 86,400
Human mesenchymal stem cells (HMS) (per tube) 24,700 49,400
EBV transformed B cell lines derived from Japanese (HEV) (per tube) 15,400 30,800
Sonoda-Tajima Collection (HSC): EBV-transformed B cell lines derived from various human ethnic groups (per tube) 15,400 30,800
Goto Collection (GMC): EBV transformed B cell lines and primary fibroblasts derived from Werner syndrome patients (per tube) 15,400 30,800
Cell line validation testing Mycoplasma test 19,500 19,500
Short tandem repeat polymorphism analysis test for human cell lines 18,500 18,500
  • (*1) This refers to the use of our bioresource in research for not-for-profit academic purpose by a non-profit organization. Category I MTA is needed.
  • (*2) This refers to the use of our bioresource in research for the following cases. Category II MTA is needed.
    • For research to be conducted by for-profit organizations
    • For collaborative research between for-profit organization and not-for-profit organization
    • For research by not-for-profit organization outsourced and sponsored by for-profit organization
    • For for-profit research by not-for-profit organization including R&D with the aim of patent acquisition
  • For Cell lines containing fluorescent proteins owned by, or licensed to, Clontech Laboratories, Inc., a license fee is separately required per cell line.
  • For-profit organizations must contact iPS Academia Japan, Inc prior to ordering.



Gene Bank (Gene Engineering Division)

Fee (JPY)
For use in research for not-for-profit academic purpose (*6) For use in research for-profit-research purpose (*7)
Clone and host (per tube)(*1)(*2) 8,640 17,280
Recombinant Adenovirus (per tube) 33,900 67,800
Library (per tube) 33,900 67,800
Microbial genomic DNA (one micro gram)(*3) 17,000 34,000
Mouse DNA (ten micro gram)(*4) 3,100 6,200
15K cDNA clone set (per set)(*5) 938,100 1,876,200
7.4K cDNA clone set (per set)(*5) 466,100 932,200
S. pombe ORFeome clone set (per set)(*5) 306,800 613,600
Thermus thermophilus expression plasmid clone set (per set)(*5) 135,000 270,000
  • (*1)  For expression clones containing mammalian cDNA produced by the Gateway®; Technology, a license fee of JPY 1,250 is separately required per clone. For a for-profit organization, it is necessary to obtain a license from Life Technology Inc.
  • (*2)  "Clone and host" includes depisited clones, vectors and host microorganisms.
  • (*3)  You can order Microbial genomic DNA from either the Gene Engineering Division or the Microbe Division. Shipments will be made by the Gene Engineering Division.
  • (*4)  You can order Mouse DNA from either the Gene Engineering Division or the Experimental Animal Division. Shipments will be made by the Gene Engineering Division.
  • (*5)  Clone sets require an additional shipping charge.
  • (*6) This refers to the use of our bioresource in research for not-for-profit academic purpose by a non-profit organization. Category I MTA is needed.
  • (*7) This refers to the use of our bioresource in research for the following cases. Category II MTA is needed.
    • For research to be conducted by for-profit organizations
    • For collaborative research between for-profit organization and not-for-profit organization
    • For research by not-for-profit organization outsourced and sponsored by for-profit organization
    • For for-profit research by not-for-profit organization including R&D with the aim of patent acquisition
  • For DNA resources containing fluorescent proteins owned by, or licensed to, Clontech Laboratories, Inc., a license fee is separately required per clone.
  • We offer volume discounts for orders of 20 tubes or more of clones, hosts or genomic DNA.



Japan Collection of Microorganisms (Microbe Division)

Fee (JPY)
For use in research for not-for-profit academic purpose (*2) For use in research for-profit-research purpose (*3)
Freeze-dried or L-dried culture (*1) 5,400 10,800
Frozen culture with dry ice (per vial) 5,400 10,800
Actively growing culture of a microbial strain that cannot be preserved as a dried culture (per vial) 8,640 17,280
Actively growing culture on request (per vial) 16,200 32,400
Microbial genomic DNA (one micro gram) (per vial) 17,000 34,000
  • (*1)  Including a frozen-thawed culture (in a plastic tube) of some fungi.
  • (*2) This refers to the use of our bioresource in research for not-for-profit academic purpose by a non-profit organization. Category I MTA is needed.
  • (*3) This refers to the use of our bioresource in research for the following cases. Category II MTA is needed.
    • For research to be conducted by for-profit organizations
    • For collaborative research between for-profit organization and not-for-profit organization
    • For research by not-for-profit organization outsourced and sponsored by for-profit organization
    • For for-profit research by not-for-profit organization including R&D with the aim of patent acquisition
  • Shipping costs will be charged to overseas' users.
  • You can order Microbial genomic DNA from either the Gene Engineering Division or the Microbe Division. Shipments will be made by the Gene Engineering Division.
  • We offer volume discounts for orders of 20 strains or more of microbes.
For advanced users

Bioresource lineup See all

New Information Close

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License agreement between Clontech and RIKEN BRC on Fluorescent Proteins
Quality Examination and Information Release Policy on Our Bioresources
International Program Associate