What are Bioresources (for first visitor) ?
Overview the general flow to get bioresource of your interest
Feel free to consult with our technical experts.
Mammalian N-terminal acetyltransferases (Nats) cotranslationally acetylates N-termini (at the α amino group) of 80–90% of human proteins. Despite the prevalence, the biological functions of protein N-terminal acetylation and NATs are still largely unknown.
Importantly, mutation of N-α-acetyltransferase 10 protein (Naa10p) the catalytic subunit of NatA complex is linked to severe developmental defects including mental retardation and infancy death in the human Ogden syndrome. In contrast, overexpression of Naa10p facilitates DNA methyltransferase 1 (DNMT1) to methylate and shut down specific tumor suppressor genes, leading to lung tumorigenesis (J Clinc Invest, 2010).
In the past few years, we have been focusing on Naa10p for studying the biological functions of NatA using traditional and tissue-specific knockout (KO) mice. Here, I will present conventional and non-conventional functions of Naa10p to you by summarizing our previous and recent works. Our results not only link Naa10p mutationassociated human disease to defective DNA methylation and genomic imprinting (Molecular Cell, 2017), but also make inhibition of Naa10p enzymatic activity as a potential strategy for treating obesity (Molecular Cell, 2019; highlighted in Nat Struc Mol Biol).
RIKEN BRC will be closed from December 28, 2019 through January 5, 2020 due to New Year's holidays.
We will resume normal business from January 6, 2020.
We wish you a wonderful holiday season, and all the best for the New Year!
Nov 28, 2019
We will stop our service during the following period due to regular maintenance.
Date & time : Sun, Dec 8 10:00 - 14:00 (JST)
For this reason, during this time, you can't access our website.
We apologize for any inconvenience this may cause and ask for your understanding.
Dec 8, Website have recovered.
On November 16th 2019, Dr. Hiroshi Abe, Senior Research Scientist of the Experimental Plant Division, and his collaborators have won the Technology Award in the 54th Annual the Japanese Society for Chemical Regulation of Plants. They have been recognized for their R&D activities to produce insecticide by the application of prohydro jasmone which regulates the function of jasmonic acid. The Award is given to researchers who have made outstanding or promising achievements in the practical application that uses chemical regulation of plants.
On November 16th 2019, Dr. Shingo Kato, R & D Scientist of the Microbe Division/Japan Collection of Microorganisms (JCM), has won the Research Encouragement Award in the 20th Annual Meeting of Extremophiles for his presentation " Iron-based microbial ecosystem of extreme environments ". He was selected by the jury as the only one laureate of the year 2019 that opened up new scientific field and frontier technology in the field of extremophiles.
Dr. Yohei Hayashi, Team Leader of the iPS Cell Advanced Characterization and Development Team, was awarded the 29th Tsukuba Young Researcher's Encouragement Prize. Awards ceremony took place, followed by and memorable lectures by the award winners on November 13 at Tsukuba International Congress Center. The Prize was jointly established by the Science and Technology Promotion Foundation of Ibaraki and the Science Academy of Tsukuba, and it is given every year to only one young researcher (below 40 yrs) who have made creative accomplishments in scientific field.
Dr. Hayashi has been recognized for his proof-of-concept studies using disease-specific iPSCs derived from patients with intractable diseases for innovative treatments.