Research Highlight: A genetic twist can lead to infertility
Team Leader of the Mutagenesis and Genomics Team, RIKEN BioResource Center, Dr. Yoichi Gondo and Research & Development Scientist Dr. Takuya Murata:
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A genetic twist can lead to infertility The discovery of genital defects in a mutant mouse strain could assist studies of human infertility....>>more |
| Research Highlight | ||
Mouse strains related to this research are available from the Experimental Animal Division.
<Strains developed in this research>
RBRC06154: B6(D2)-Ctnnb1<Rgsc1880>
RBRC06153: B6.Cg-Tg(TOPGAL) Ctnnb1<Rgsc1880>
RBRC05918: B6.Cg-Tg(TOPGAL)
<Other strains used in this research>
RBRC02228: ICR.Cg-Tg(TOPGAL)
RBRC-GD000125: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000129: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000130: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000131: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000132: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000133: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000134: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000135: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000136: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000137: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000138: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000139: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC06154: B6(D2)-Ctnnb1<Rgsc1880>
RBRC06153: B6.Cg-Tg(TOPGAL) Ctnnb1<Rgsc1880>
RBRC05918: B6.Cg-Tg(TOPGAL)
<Other strains used in this research>
RBRC02228: ICR.Cg-Tg(TOPGAL)
RBRC-GD000125: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000129: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000130: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000131: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000132: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000133: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000134: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000135: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000136: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000137: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000138: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
RBRC-GD000139: Page 8 of Supplementary Information (more for acquisition: animal@brc.riken.jp)
Related Information
Original Paper on Scientific Reports 4, 6959 (2014):
β-cateninC429S mice exhibit sterility consequent to spatiotemporally sustained Wnt signalling in the internal genitalia.
Press Release from RIKEN (November 7, 2014):
A new angle on infertility
Mouse of the Month (November, 2014):
C429S mutation in the mouse β-catenin geneleads to infertility
E-MAIL News (December 5, 2014)
https://www.brc.riken.jp/lab/animal/mailnews/20141205e.html